Creatine is metabolized into creatinine by the kidneys in the body. Will taking too much creatine cause kidney dysfunction? Currently, scientists have confirmed that taking 20 grams of creatine a day does not have side effects on the human body. The only thing found is that when the body load is exceeded, diarrhea will occur, but this diarrhea will stop as the dosage is reduced; for other steroid enhancers that can cause serious side effects, creatine is really safe and reliable. .